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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics
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Due to its effects on glucose metabolism, GLP-1 and its synthetic agonists have become key pharmacological agents in the treatment of type 2 diabetes (T2D) [2]
Although endogenous GLP-1 lowers blood glucose levels, it is degraded quickly, which results in loss of its hypoglycemic effects
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