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That is why it can be swallowed at all, and why it behaves like a small-molecule drug: real oral absorption, first-pass liver metabolism, a huge volume of distribution (39 L/kg in mice), and off-target enzyme binding
Sikiric P, Radic B, Geber J, et al
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Someone with pernicious anemia and someone with a vegan diet and healthy digestion have very different situations, even if their numbers look similar
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