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These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes

They looked at the results of 39 published studies, and determined there is significant evidence that two specific pathways for detoxification are impaired in autism, and that large trials are needed for children with autism to determine if boosting the function of these two pathways will likewise improve autistic behaviors

Kuratsune H

They act as signalling molecules within the body, instructing other cells and molecules on what functions to perform

In contrast, nitro-benzyl-glutathione, a GSH analog in which the thiol group is protected, and GSSG, did not elicit this effect