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The practice appears to have originated outside conventional medical channels, often promoted through social media, wellness influencers, or unregulated online pharmacies rather than through peer-reviewed medical literature or established clinical guidelines

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Nausea, fatigue, constipation, diarrhea, bloating, and dizziness are among the commonly reported side effects, particularly during the initial phase of treatment or after a dose increase

The mechanism by which GLP-1 receptor agonists might contribute to pancreatitis risk remains unclear, but possibilities include effects on pancreatic enzyme secretion, changes in gallbladder motility leading to gallstone formation, or direct effects on pancreatic tissue