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These peptide analogues, used at pharmacological doses, achieve significant weight loss, mainly by reducing intake, as well as improving the metabolic situation in the case of diabetes or associated insulin resistance, such as in Polycystic Ovary Syndrome

Regular monitoring of thyroid function tests (TSH and free T4) should continue as per usual clinical practice, particularly if significant weight loss occurs, as this may necessitate adjustment of levothyroxine dosage

Lipid peroxidation was measured with using Bodipy 581/591 C11 (Fisher Scientific D3861) at 1 M following the manufacturers protocol

Email response is also reasonably quick

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