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The STEP 1 clinical trial demonstrated average weight loss of approximately 15% of body weight over 68 weeks with semaglutide 2.4mg, but these results were achieved in conjunction with dietary counselling and a 500 kcal per day calorie deficit, as highlighted in NICE TA875
In an emailed statement to The Crimson, Habener wrote that it was gratifying to see that these contributions are helping to alleviate diabetes and obesity-associated co-morbidities in people throughout the world. Habener added that in addition to lowering blood sugar levels and promoting weight loss, GLP-1 receptor antagonists can have a slew of other health benefits, including reducing the risk of heart attacks, stroke, and death in non-diabetic patients with cardiovascular disease
The difficulty of GLP-1 receptor agonist oral products is that GLP-1 is easily degraded by enzymes in the gastrointestinal tract
Common Side Effects Include: Nausea Vomiting Diarrhea Constipation Loss of appetite Fatigue For dialysis patients, these symptoms can increase the risk of: Dehydration Malnutrition Muscle loss Electrolyte imbalance Low blood pressure during treatment Because dialysis already places stress on fluid balance, vomiting or poor oral intake can become serious quickly
