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Peptides with half-lives of 1224 h may be viable with twice-daily dosing or if other enabling properties (very high potency, very wide therapeutic window) partially compensate
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Owji AA, Khoshdel Z, Sanea F et al (2002b) Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus
In the SURMOUNT-1 trial, tirzepatide 15 mg produced a mean weight reduction of 22.5% over 72 weeks in adults without diabetes, highlighting the potential value of multi-receptor metabolic therapy
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