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In order to preserve its effectiveness, the skin is sustained endogenously (protected from within) through an oxidant-antioxidant balance

Repeated freeze-thaw cycles: Each cycle risks partial aggregation and loss of activity

The historical registration of some extract preparations (such as thymalin, epithalamin, and cortexin) within Russia does not constitute approval in Western regulatory systems, which apply far more stringent efficacy, manufacturing, and pharmacovigilance requirements before a product may be marketed for human use

Qian J, Si Y, Chen Y, Zhu Y, Zhu J, Mo C, et al

Both Routes Simultaneously Community sources commonly describe running topical and injectable GHK-Cu concurrently -- topical for skin-specific goals and injectable for systemic distribution