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Analysis of tumour samples showed an upregulation of p21 CIP1 and p27 on palbociclib treatment and a significant reduction when compared with the palbociclib + RSL3-treated mice (Fig

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Importantly, these trials exhibited a high degree of heterogeneity in terms of the types of substances studied, patient characteristics, and treatment protocols, which posed significant challenges to drawing definitive conclusions

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This typically resolves by the second week and may actually indicate the peptide is working effectively