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Goodman et al., 2004)
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers
The chromone scaffold of Compound 69 interacts with conserved Q726 via hydrogen bonding and with a hydrophobic clamp formed by F729 and I692/F696 through stacking interactions
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