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While semaglutide and tirzepatide share this foundation, they differ in how powerfully they influence your body
ARDs, which include rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, and axial spondyloarthritis, are characterised with chronic systemic inflammation that accelerates atherogenesis and substantially increases premature cardiovascular death
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This is because, when taken orally, L-carnitine must pass through the digestive system where it is subject to breakdown and alteration before it can be absorbed into the bloodstream
The different ones GI discontinuation rate: 5.6% of semaglutide (Wegovy) users stopped due to GI side effects, vs 2.7% of Tirzepatide (Mounjaro) users Diarrhoea: Common with Mounjaro because of its dual action Nausea and constipation: Seen more in Wegovy MHRA NAION warning (February 2026) : Both medications carry an updated warning about a very rare but serious eye condition (non-arteritic anterior ischaemic optic neuropathy)
