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Moreover, although selective PDE1B and PDE10A inhibitors have demonstrated preclinical efficacy in ameliorating both positive and negative symptom-like behaviors, clinical translation has encountered challenges, including inadequate CNS penetration, dose-limiting toxicities, and variable target engagement
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Excessive activation of the ionotropic and metabotropic glutamate receptors by Hcy exacerbates excitotoxicity, leading to intracellular calcium overload, mitochondrial dysfunction, and apoptosis
Nayan Patel, PharmD, founder of Auro Wellness and CEO of Central Drugs Compounding Pharmacy
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