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mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

MT-I is identical to -MSH except that it features norleucine instead of methionine in the fourth position, and D-phenylalanine instead of L-phenylalanine in the seventh position

Model building and refinement The cryo-EM structures of the and GLP-1(7-36)GLP-1RG s (PDB code: 6X18) 14 and LSN3318839GLP-1(7-36)GLP-1RG s (PDB code: 6VCB) 22 were employed as the initial templates for modeling the GLP-1(9-36)GLP-1RG s and LSN3318839GLP-1(9-36)GLP-1RG s complexes, respectively

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