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2.1 Advances in patient-centered modeling of neurodegenerative disorders Neurodegenerative diseases (NDDs) are a diverse group of complex conditions characterized by progressive and irreversible dysfunction of the brain due to the continuous loss of specific neuron populations that are susceptible to degeneration (Forman et al., 2004)

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Abbreviations A: Amyloid- NPY1R: Neuropeptide Y Y1 receptor VIP: Vasoactive intestinal peptide CRH : Corticotropin-Releasing Hormone ACTH : Adrenocorticotropic Hormone CCK: Cholecystokinin DSIP: Delta Sleep-Inducing Peptide GPCR: G protein-coupled receptors References Aguilera G (1994) Regulation of pituitary ACTH secretion during chronic stress

References Diuretic efficacy of high dose furosemide in severe heart failure: Bolus injection versus continuous infusion The objective of this study was to evaluate the efficacy of high-dose furosemide as a continuous infusion compared with a bolus injection of equal doses in patients with severe heart failure