[6] [3] [10] A mild deficiency may not cause any discernible symptoms, but moderate deficiency can cause various symptoms, such as feeling tired, lightheadedness, headaches, cold intolerance, pale skin, sore tongue, upset stomach, loss of appetite, hair and skin color changes, numbness or tingling (pins and needles) of the fingers and toes, and tinnitus, and vision, cognitive or psychological problems
More serious but less common adverse effects include pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in animal studies, though the clinical relevance in humans remains uncertain)
Bioavailability of oral NAC can vary between 610%, probably due to extensive first-pass metabolism in the gut wall and liver
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