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Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

History [edit] In the 1960s, the adamantane derivative amantadine (1-aminoadamantane) was developed as an antiviral drug for the treatment of influenza

Although exercise mimetics offer a scalable and mechanism-informed therapeutic strategy, most evidence to date remains preclinical, and substantial challenges related to pharmacokinetics, safety, target engagement, and patient heterogeneity must be overcome before clinical implementation

Jiang et al., 2021), and has become a hot spot in biological research in recent years

Why researchers combine them The two peptides target mechanistically distinct pathways