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Even though istradefylline was suspected to positively affect cognitive dysfunction and postural abnormalities in patients with PD, short-term clinical trials did not show benefits on cognition [76]

These results are striking, but it is essential to keep them in context: Phase 2 studies are relatively small and shorter-term, and larger Phase 3 trials are required to confirm efficacy and characterize long-term safety

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Burning or pain that lasts well beyond that, or swelling that grows over hours, can mean the shot went too deep (IM instead of SubQ) or a reaction to the preservative reasons to check technique and talk to your provider