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"Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis." Proc Natl Acad Sci

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N-acetyl-cysteine administration supplies the cysteine necessary for GSH synthesis and concomitantly reduces hyperhomocysteinemia, improving GSH peroxidase activity and reducing oxidative stress (159)

Additionally, overexpression of alpha-synuclein increases the phosphorylation of NMDARs, thereby increasing the expression of NR1 and NR2B subunits and increasing the sensitivity of NMDARs to glutamate excitotoxicity (Yang et al., 2016)

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