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Interestingly, interventions that boost NAD + levels resulted in extended lifespan in worms and mice 108,109,111,247 , suggesting a therapeutic potential for raising NAD + in various pathological conditions or age-associated diseases

Thus, the present findings should be cautiously interpreted, recognizing the potential for multiple interacting pathways and the need for further research

however, compared with the H/R group, treatment with semaglutide + H/R reversed this effect, resulting in a substantial increase in ATP levels (Fig