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doi: 10.1186/s12951-023-02146-0 115 KwakGKimDNamGHWangSYKimISKimSHet al
An RCT in 50 infertile men found that NAC (600 mg/day for 3 months) significantly improved sperm concentration, motility, and morphology and reduced oxidative stress markers (Ciftci et al., Urology, 2009) [69]
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Therefore, accelerated oxidation of biomolecules acts both as a product and causal for disease manifestation which is further exacerbated by failure of antioxidant system and loss of redox sensing capabilities of chaperone DJ-1 18,19
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