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successfully predicted cetuximab sensitivity in CRC PDX models by incorporating multi-omics data, providing a novel strategy for precision screening of targeted therapies [181]
They are also contraindicated in those with personal or family history of medullary thyroid carcinoma and those with multiple endocrine neoplasia type 2
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In rare cases where rhabdomyolysis is confirmed, tirzepatide should be discontinued
In the context of lipid metabolism, targeting pathways such as ether lipid synthesis, fatty acid synthase (FASN), or the ACLY/ACC axis has been shown to induce mitochondrial stress and ROS accumulation, thereby enhancing apoptotic responses [144]
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