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NCT04847557) seeks to evaluate the effect of tirzepatide (is a dual agonist for the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors) over 52 weeks in 700 patients with heart failure with preserved ejection fraction (HFpEF) and obesity
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It says it stands by the medicines effectiveness for severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and is working with the agency on a path forward while emphasizing ongoing safety monitoring and the drugs clinical evidence
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Currently, their use in Parkinson's remains experimental, with no NHS or NICE recommendation outside of clinical trials
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