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This suggests that targeted combination approaches may provide comparable efficacy with potentially better tolerability

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The aim of this study was to prove our hypothesis that A-GSH functionalization increases brain endothelial internalization and BBB permeability of polymeric nanoparticles coupled with active agents, namely dopamine and ibuprofen, which have low brain penetration

In RA and AxSpA patients, low disease activity or remission induced by biologic disease modifying anti-rheumatic drugs (bDMARDs), mainly anti-TNFs, resulted in stabilization of subclinical atherosclerosis [57, 58], while a meta-analysis shows amelioration of atherosclerosis and arterial stiffness in anti-TNF--treated patients with inflammatory arthritis (RA, PsA, AxSpA) [59]