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13b, Supplementary Table 9), indicating that the interactions between the C-terminal tyrosine and RAMP3 can compensate, in this peptide context, the reduced CTR ECD affinity derived from the P37Y substitution

Peptide state influences vulnerability

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These structural distinctions, in turn, may contribute to the distinct pharmacological profile of Cagri when assessed in proximal, selective, assays of primary transducer interaction