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Thus, although negative selection against VAMP1 reduces cleavage on SNARE targets, evolution on procaspase-1 appears to confer caspase-like substrate preferences that include IL-1 or substrates with complete homology to the P2P4 of procaspase-1 such as ORC1 (residues 691707)

Redox Biol 42:101887 Marrocco I, Altieri F, Peluso I (2017) Measurement and clinical significance of biomarkers of oxidative stress in humans

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