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Three key findings emerged from this study: (1) PRMT1 upregulation in injured TECs drives UBE2m methylation at R169, (2) methylated UBE2m promotes NEDD4 neddylation and subsequent PPAR ubiquitination, and (3) this pathway is clinically relevant in stone patients, correlating with renal function decline
Clinical treatment strategy for MTHFR-related psychiatric disorders As MTHFR plays a critical role in one-carbon metabolism, which is composed of folate, homocysteine, vitamin B12, and methylation of DNA, mutation of specific gene locus on MTHFR and correlative enzyme activity decline will affect various of physiological events as well as some pathology states, including psychiatric disorders
Park et al., 2023)
Our data suggest activation of ferroptotic pathways could be one of the primary drivers of intracellular (and extracellular) redox imbalance in T2-high asthma
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