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Keshavarzian A, Holmes EW, Patel M, Iber F, Fields JZ, Pethkar S

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5 Even modest weight loss is clinically meaningful: reductions of 5% of baseline weight can improve blood pressure, glucose levels and cardiovascular risk

This dual GIP and GLP-1 agonist approach is what distinguishes tirzepatide pharmacologically and likely explains why clinical trials have reported higher average weight-loss outcomes with tirzepatide compared to semaglutide