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The rationale rests more on theoretical benefit and observed clinical patterns than controlled trial evidence
High levels of body fat especially visceral fat surrounding internal organs increase the likelihood of insulin resistance and type 2 diabetes and contribute to hypertension, high cholesterol and an increased risk of cardiovascular diseases such as heart attack and stroke
Results In the GLP-1 RA vs SGLT-2 inhibitor cohort (2014-2022) we identified 83,464 new users of GLP-1 RAs and 78,366 new users of SGLT-2 inhibitors
Results in animal studies In rodent experiments led by Dr
These newer-generation SUs are often superior to other drug classes in terms of speed in achieving in glycemic control, offer better protection against adverse cardiac and renal outcomes, and show low incidences of untoward side effects that can rival those of other DM drugs, making them the safer option among SUs
