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The absence of drug affinity complex modification results in a shorter receptor interaction window, allowing for transient activation that aligns with pulsatile signaling models
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Intriguingly, both the platypus and echidna GLP-1 peptides displayed a distinct pattern of signalling in comparison to hGLP-1 and the clinically approved mimetic Ex-4, which was apparent at both the human and platypus GLP-1 receptors (Fig
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