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Since the promoter region of MITF contains the consensus CRE sequence, the expression of MITF can also be increased by -MSH stimulation in a cAMP-dependent manner (23)

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In a Phase I study with recombinant human thymosin beta-4, the terminal half-life was about 0.5 to 2.08 hours, for example 1.02 hours at 0.5 microg/kg and up to 2.08 hours at 25 microg/kg, with linear, non-accumulating kinetics and dose-proportional Cmax Wang et al., 2021

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