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Therefore, targeting mitochondrial mechanisms makes sense

The Semaglutide Treatment Effect in People With Obesity (STEP) trials have found that obese patients who take 2.4 mg of semaglutide weekly lose an average of 6% of their body weight by week 12

If a patient is experiencing significant side effects, the dose can be held or reduced rather than stopping treatment entirely

N Engl J Med 389:10691084 Pandey A, LaMonte M, Klein L et al (2017) Relationship between physical activity, body mass index, and risk of heart failure

The high cost of the brand name drugs and lack of insurance coverage has led to "these sort of gray markets that are cropping up all over the place that are forcing patients to make these trade-offs," Dr