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The potency of DO3A-Tuna-2 at human recombinant GCGR (EC 50 0.4 pM) is comparable to that of native glucagon (EC 50 0.5 pM)

MT-2s cyclic structure confers significantly enhanced resistance to enzymatic degradation, with an effective research half-life of approximately one to two hours, providing a substantially wider in vitro and pre-clinical experimental window than the endogenous compound

Clinically, low albumin (e.g., in liver disease or nephrotic syndrome) can lead to edema due to decreased oncotic pressure

The viscosity and polarity of the solvents effect was the same as exhibited in the degradation of poly-caprolactone

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