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Upon pooled analysis, the ORR and disease control rates (DCR) of Child-Pugh B patients treated with ICIs were 14% (95% confidence interval [CI] 11-17%) and 46% (95%CI 36-56%), with a median OS and median progression-free survival (PFS) of 5.49 (95%CI 3.57-7.42) and 2.68 (95%CI 1.85-3.52) months, respectively
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This can result in a variation in levels of 1030% from day to day and up to 45% within 24 h
Britt, M.D., Xiaoming Fu, M.S., Yuping Wu, Ph.D., and Stanley L
La dosis se aumenta gradualmente en incrementos de 2.5 mg cada 4 semanas segn la respuesta clnica y tolerabilidad, hasta alcanzar dosis de mantenimiento de 5-15 mg semanales
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