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Conclusions In people living with type 2 diabetes inadequately managed with GLP-1 RA therapy, with or without additional oral glucose-lowering medications, switching to once-weekly IcoSema, compared with once-weekly semaglutide 1.0 mg, demonstrated statistical superiority in HbA 1c reduction, similar rates of clinically significant or severe hypoglycaemic episodes and comparable gastrointestinal tolerability
However, I found that consistent weekly microdosing works best for me not just for weight maintenance, but for all the additional health benefits like reduced inflammation, hormone support, and overall wellbeing
Tesamorelin stimulates GH release through the GHRH receptor pathway, while Ipamorelin activates GHS-R1a receptors
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