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[127] [128] Synthesis [edit] Biosynthesis [edit] Vitamin B 12 is derived from a tetrapyrrolic structural framework created by the enzymes deaminase and cosynthetase which transform aminolevulinic acid via porphobilinogen and hydroxymethylbilane to uroporphyrinogen III

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Boosting it could extend healthy lifespan."[13][3] He advocates for precursors but sees value in inhibitors like 5-Amino-1MQ to maximize NAD+ utility