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In HG-induced MPC-5 and STZ-induced SD rat models, Icariin (ICA) can increase Sesn2-induced mitophagy via the Keap1-Nrf2/HO-1 axis, thereby inhibiting the activation of NLRP3 inflammatory vesicles and exerting a renoprotective effect [135]
Both drugs require frequent lab monitoring visits, which can impact duration of use
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It is also recommended by some doctors for treating hyperlipidemia and reducing the risk of major cardiovascular events. Medical Indications This medication is prescribed for: Lowering high cholesterol levels in adults and children over 10 years of age
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