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Both in vivo and in vitro studies demonstrated that liraglutide treatment inhibited the activation of NLRP3 inflammasome in the lungs of pulmonary fibrosis model mice and in profibrotic cytokine-challenged fibroblasts
Hosseini, S., Zorab, M
Animal study doses cannot be extrapolated to other species due to profound differences in melanocortin receptor expression, distribution, pharmacokinetics, metabolic rates, and species-specific neural circuit organization
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