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[1] The honest summary is that the animal record is heterogeneous: some biomarkers move favorably in some strains and protocols, but a clean, reproducible, cross-laboratory lifespan-extension signal is not established, and the variability across experiments is itself a reason for caution rather than a footnote to be skipped

Any discussion of potential benefits should remain tied to laboratory, animal, or analytical research rather than human outcomes

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Liver fat fraction, measured by MRI-PDFF in a subgroup, decreased substantially, supporting a potential role in MASLD management

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