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Key distinctions in the evidence: Tesamorelin: licensed in the US, narrowly indicated, established in HIV-related lipodystrophy, with effects that reverse on stopping treatment Retatrutide: investigational, broader metabolic potential, not yet approved anywhere globally Patients and clinicians should interpret early-phase data for retatrutide with appropriate caution

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The receptors have adapted to the new baseline

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However, some patients may experience a rapid progression over several days

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(download XLSX Differentially expressed genes, their log2 fold changes, p -values and FDR corrected p -values per comparison

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