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These effects were mediated through downstream activation of transcription factors including c-Fos, c-Jun, and EGR-1, which regulate genes involved in cell cycle progression, extracellular matrix remodelling, and angiogenic signalling
10.1002/stem.3101 Stem Cells 131 WangL.AzadN.KongkaneramitL.ChenF.LuY.JiangB.-H.et al (2008)
PMID: 24942808 DOI: 10.1111/jth.12637 Patrono C et al (2008): Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Insulin, the very first lab-made peptide, signaled the launch of modern peptide therapeutics in 1921
They are not FDA-approved
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