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Taken together, these pharmacokinetic findings indicate that the centrally mediated effects of GLP-1RAs are likely due to limited brain penetration or action at sites adjacent to the BBB, rather than widespread distribution throughout the central nervous system

Some evidence suggests that certain cardiometabolic benefits may persist but only modestly

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Makarewicz M, Drod I, Tarko T, Duda-Chodak A

42 Pre-lunch plasma concentrations of total ghrelin and PYY were also found not to be associated with lunch energy intake in healthy women