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Per i risultati degli studi rispetto alle associazioni, agli effetti sul controllo glicemico e sugli eventi cardiovascolari e alle popolazioni studiate, vedere i paragrafi 4.4, 4.5 e 5.1
Iannucci A, Caneparo V, Raviola S et al (2020) Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding
Concurrently, GLP-1 also reduces fat build-up in the liver by activating AMPK, which then inhibits fatty acid synthesis while promoting the breakdown of fatty acids (beta-oxidation), leading to less lipid droplet accumulation in hepatocytes
Mechanisms that fine-tune PRR-mediated responses include transcriptional and fpost-transcriptional regulation, protein degradation, subcellular localization, and the recruitment of amplifiers and inhibitors, along with metabolic and microbial factors