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The SOUL trial (2025), a large-scale, double-blind, placebo-controlled study, evaluated once-daily oral semaglutide in 9,650 patients with T2DM and established atherosclerotic cardiovascular disease, chronic kidney disease, or both
Beyond simple weight reduction, decreased visceral adiposity specifically improves insulin sensitivity, reduces systemic inflammation, and normalizes adipokine secretion, all contributing to favorable lipid changes
How do I know my tirzepatide concentration
Here's an overview of the kind of weight loss results you might expect: Clinical Trial Averages: In a major trial (SURMOUNT-1) involving over 2,500 adults without diabetes, tirzepatide helped patients lose an average of about 15% of their starting body weight at the mid-range doses, and up to 22.5% of body weight on the highest 15 mg dose over 72 weeks [4]