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Piperine co-administration inhibits phase II glucuronidation and sulphation via competitive enzyme inhibition, thereby augmenting systemic curcumin exposure by an estimated 2- to 20-fold in human pharmacokinetic studies, although the magnitude of enhancement varies with dose and timing (Figure 1)

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A body fat percentage above 25% in men or 32% in women indicates excess adiposity even if BMI falls in the normal range

J Controlled Release (2019) 316:35980

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