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Highmark International Drug Sourcing International Drug Sourcing has become a popular topic For clients in the Self-Funded and/or Large Market segment, where latitude may exist to apply Pharmacy Carve-out strategy, Highmark has provided commentary below For New to Blue prospects or Renewal clients considering Third Party relationship that apply this strategy, please view Highmarks analysis for consideration

Chapter 4 Tissue carbohydrate metabolism, gluconeogenesis and hormonal and environmental influences

Most patients notice appetite suppression within 35 days of their first 0.25 mg dose, though full effect builds over the first 23 weeks

A significant challenge with using GLP-1 drugs is the high rates at which patients stop using them, often driven by their exorbitant cost or the emergence of adverse effects

Verify your 2026 benefits: During open enrollment, confirm whether your employer plan will cover Wegovy next year Consider plan switching: If your current plan is dropping coverage, evaluate other options during open enrollment Medicare patients: Monitor CMS.gov for Medicare coverage policy changes