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Dry mouth, darker urine, headaches, dizziness, or that wiped-out feeling for no obvious reason can all be clues that fluids have quietly gotten too low

A prototypical example is the Zellweger spectrum disorders (ZSD), which arise from mutations in PEX genes encoding RING-type zinc finger peroxins such as PEX12 and PEX10, whose zinc-coordinating motifs are essential for peroxisome assembly and protein import 159,160