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Tirzepatide, when used in conjunction with Semaglutide, has been shown in clinical studies to substantially reduce body weight when administered weekly

Biliary complications (cholelithiasis, cholecystitis) represent a class effect attributable to reduced gallbladder motility, with incidence approximately 1.5-2.5-fold higher than placebo in long-term trials

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In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients