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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Activated microglia and astrocytes can produce ROS and pro-inflammatory cytokines, creating a vicious cycle of oxidative damage and inflammation
But it operates on a timeframe that extends well beyond annual budget cycles
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However, inhibition of FAO in the cerebrovasculature even in the presence of glucose leads to defective cation transport (Steinberg et al., 1977)
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