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The PRX1(P233stop) and the PRX1(C91A) constructs were generated from the PRX1(WT) construct by sitedirected mutagenesis
The first GSH molecule is activated at the 1st glutathione-interaction site of the glutaredoxin
Comparative proteome abundance and data analysis were performed using MaxQuant software (version 1.3.0.5 67 ), with Andromeda used for database searching and Perseus used to organize the data (version 1.4.1.3)
The catalytic cycle involves three distinct basic reactions
Administration Format 5-Amino-1MQ is typically administered in oral capsule form , unlike many peptides that require subcutaneous injection
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