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In animal models concerning the central nervous system, interactions of BPC-157 with the dopaminergic (D2 receptors), GABAergic, and serotonergic systems have been described

doses over ~1 mg/day are not associated with added benefit

Reported adverse effects in human supplementation trials are rare but may include gastrointestinal discomfort, skin pigmentation, and hormonal modulation at higher doses (Yoshida et al., 2010)

For comparison, MassHealth does cover bariatric surgery for patients with BMI over 40 (or BMI over 35 with comorbidities), with approximately 1,200 procedures performed annually at a total cost of $31 million

Zepbound saw a 12% increase in uncovered patients, exceeding 109 million